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说明： EGFR/PDGFR-kinase inhibitor
别名： Tyrphostin AG 213
化学名： (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenthioamide
生物活性 for AG 213
Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC50 values are 2.4 and 3 μM respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro. Also weakly inhibits protein kinase C (IC50 = 60 μM).
技术数据 for AG 213
| 分子量 | 220.25 |
| 公式 | C10H8N2O2S |
| 储存 | Desiccate at +4°C |
| CAS Number | 122520-86-9 |
| Smiles | OC1=C(O)C=CC(\C=C(C(N)=S)/C#N)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AG 213
参考文献 for AG 213
参考文献是支持产品生物活性的出版物。
Gazit et al (1989) Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344 PMID: 2552117
Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782 PMID: 7892601
Plouffe et al (2006) Role of tyrosine kinase receptors in angiotensin II AT2 receptor signaling: Involvement in neurite outgrowth and in p42/p44mapk activation in NG108-15 cells. Endocrinology 147 4646 PMID: 16809450
Yaish et al (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242 933 PMID: 3263702
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