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Submit ReviewAGK 2
说明： Selective SIRT2 inhibitor
化学名： 2-Cyano-3-[[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
纯度： ≥98% (HPLC)
生物活性 for AGK 2
Selective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.
技术数据 for AGK 2
| 分子量 | 434.27 |
| 公式 | C23H13Cl2N3O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 304896-28-4 |
| PubChem ID | 2130404 |
| InChI Key | SVENPFFEMUOOGK-SDNWHVSQSA-N |
| Smiles | O=C(/C(C#N)=C/C3=CC=C(C4=C(Cl)C=CC(Cl)=C4)O3)NC2=CC=CC1=NC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AGK 2
参考文献 for AGK 2
参考文献是支持产品生物活性的出版物。
Outeiro et al (2007) Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease. Science 317 516 PMID: 17588900
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关键词: AGK 2, AGK 2 supplier, Selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, AGK2, Class, III, HDACs, (Sirtuins), 3233, Tocris Bioscience
3 篇 AGK 2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AGK 2 的部分引用包括：
Newton et al (2014) Is SIRT2 required for necroptosis? Nature 506 E4 PMID: 24572428
Snider et al (2013) Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. Adipocyte 200 241 PMID: 23358244
Xu et al (2013) Temporal analysis of protein lysine acetylation during adipocyte differentiation. J Pharmacol Exp Ther 2 33 PMID: 23700550
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