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Submit ReviewAH 11110 hydrochloride
Discontinued Product
0998 has been discontinued.
View all Adrenergic α<sub>1</sub> Receptors products.
说明： Subtype-selective α1B ligand
化学名： 4-Imino-1-(2-phenylphenoxy)-4-piperidinebutan-2-ol hydrochloride
纯度： ≥98% (HPLC)
生物活性 for AH 11110 hydrochloride
AH 11110 hydrochloride is a subtype-selective ligand for the α1B-adrenoceptor. The pKi values for binding to rat fibroblast cell membranes expressing α1B (hamster), α1A (bovine) and α1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α1 subtypes and α2 receptors in smooth muscle preparations.
技术数据 for AH 11110 hydrochloride
| 分子量 | 374.91 |
| 公式 | C21H26N2O2.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 179388-65-9 |
| PubChem ID | 9907616 |
| InChI Key | WWHGFIXWBLHHQB-UHFFFAOYSA-N |
| Smiles | Cl.OC(COC1=C(C=CC=C1)C1=CC=CC=C1)CC(=N)N1CCCCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AH 11110 hydrochloride
参考文献 for AH 11110 hydrochloride
参考文献是支持产品生物活性的出版物。
Eltze et al (2001) Failure of AH11110A to functionally discriminate between α1-adrenoceptor subtypes A, B and D or between α1- and α2-adrenoceptors. Eur.J.Pharmacol. 415 265 PMID: 11275009
Saussy et al (1996) Structure-activity relationships of a series of busp. analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype. J.Pharmacol.Exp.Ther. 278 136 PMID: 8764344
King et al (1994) AH 11110A is selective for the α1B-subtype of α1-adrenoceptors. Soc.Neurosci.Abstr. 20 526
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关键词: AH 11110 hydrochloride, AH 11110 hydrochloride supplier, Subtype-selective, α1B-adrenoceptor, alpha1B-adrenoceptor, α1b-adrenergic, alpha1b-adrenergic, a1b-adrenoceptor, a1b-adrenergic, ligands, Receptors, AH11110, hydrochloride, Adrenergic, Alpha-1, 0998, Tocris Bioscience
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.