Ailanthone

Discontinued Product

6161 has been discontinued.

View all Androgen Receptors products.
说明: Potent inhibitor of androgen receptor (AR)
化学名: (1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione
纯度: ≥98% (HPLC)
说明书
引用文献
评论

生物活性 for Ailanthone

Ailanthone is a potent androgen receptor (AR) inhibitor (IC50 = 69 nM). Disrupts the AR-chaperone complex by binding p23 and blocking AR interaction with HSP90 causing UPS degradation of AR. Inhibits Huh7 cancer cell growth via G0/G1 cell cycle arrest and apoptosis in vitro and in vivo. Inhibits growth and metastasis of certain prostate cancer cell lines. Orally bioavailable.

技术数据 for Ailanthone

分子量 376.4
公式 C20H24O7
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 981-15-7
PubChem ID 72965
InChI Key WBBVXGHSWZIJST-RLQYZCPESA-N
Smiles C=C1[C@]([C@]([C@]2([H])[C@@]3(O)[C@@H]1O)(CO3)[C@@](O4)([H])C[C@@]([C@]2(C)[C@@H]5O)([H])C(C)=CC5=O)([H])CC4=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Ailanthone

参考文献是支持产品生物活性的出版物。

He et al (2015) Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat.Commun. 7 13122 PMID: 27959342

Zhuo et al (2015) Ailanthone inhibits Huh7 cancer cell growth via cell cycle arrest and apoptosis in vitro and in vivo. Sci.Rep. 5 16185 PMID: 26525771

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关键词: Ailanthone, Ailanthone supplier, Inhibitors, Inhibits, AR, Androgen, Receptor, p23, HSP90, Ubiquitin, Protease, System, UPS, apoptosis, prostate, cancer, Huh7, CRPC, castration-resistant, 6161, Tocris Bioscience

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