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Submit ReviewAilanthone is a potent androgen receptor (AR) inhibitor (IC50 = 69 nM). Disrupts the AR-chaperone complex by binding p23 and blocking AR interaction with HSP90 causing UPS degradation of AR. Inhibits Huh7 cancer cell growth via G0/G1 cell cycle arrest and apoptosis in vitro and in vivo. Inhibits growth and metastasis of certain prostate cancer cell lines. Orally bioavailable.
分子量 | 376.4 |
公式 | C20H24O7 |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 981-15-7 |
PubChem ID | 72965 |
InChI Key | WBBVXGHSWZIJST-RLQYZCPESA-N |
Smiles | C=C1[C@]([C@]([C@]2([H])[C@@]3(O)[C@@H]1O)(CO3)[C@@](O4)([H])C[C@@]([C@]2(C)[C@@H]5O)([H])C(C)=CC5=O)([H])CC4=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
He et al (2015) Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat.Commun. 7 13122 PMID: 27959342
Zhuo et al (2015) Ailanthone inhibits Huh7 cancer cell growth via cell cycle arrest and apoptosis in vitro and in vivo. Sci.Rep. 5 16185 PMID: 26525771
关键词: Ailanthone, Ailanthone supplier, Inhibitors, Inhibits, AR, Androgen, Receptor, p23, HSP90, Ubiquitin, Protease, System, UPS, apoptosis, prostate, cancer, Huh7, CRPC, castration-resistant, 6161, Tocris Bioscience
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