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Submit ReviewAlfuzosin hydrochloride
Discontinued Product
3305 has been discontinued.
View all Adrenergic α<sub>1</sub> Receptors products.
说明： Uroselective α1 antagonist
化学名： N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Alfuzosin hydrochloride
Alfuzosin hydrochloride is a functionally uro-selective α1 adrenoceptor antagonist that does not discriminate between α1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50 = 7.64) in vitro.
技术数据 for Alfuzosin hydrochloride
| 分子量 | 425.91 |
| 公式 | C19H27N5O4.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 81403-68-1 |
| PubChem ID | 71764 |
| InChI Key | YTNKWDJILNVLGX-UHFFFAOYSA-N |
| Smiles | NC2=NC(N(C)CCCNC(C3CCCO3)=O)=NC1=CC(OC)=C(OC)C=C12.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Alfuzosin hydrochloride
参考文献 for Alfuzosin hydrochloride
参考文献是支持产品生物活性的出版物。
Palea and Barras (2003) Comparison of the relaxant effects of alfuzosin, phentol. and silde. on rabbit isolated corpus cavernosum. BJU Int. 91 873 PMID: 12780851
Lee (2003) Alfuzosin hydrocholride for the treatment of benign prostatic hyperplasia. Am.J.Health Syst.Pharm. 60 1426 PMID: 12892027
Yamaguchi et al (2005) Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes. J.Smooth Muscle Res. 41 247 PMID: 16428864
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关键词: Alfuzosin hydrochloride, Alfuzosin hydrochloride supplier, Uroselective, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, antagonists, α1-adrenergic, alpha1-adrenergic, Receptors, Adrenergic, Alpha-1, 3305, Tocris Bioscience
Alfuzosin hydrochloride 的评论
平均评分: 4 (Based on 1 Review.)
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Used to investigate cell metabolism.
By
Anonymous on 02/27/2023
分析类型： In Vitro
种属： Rat
细胞系/组织： Primary hippocampal neurons
The drug was incubated at 10 μM to investigate a potential effect on cell metabolism.
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.