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Submit ReviewAllopregnanolone
说明： Positive allosteric modulator of GABAA receptors
别名： 3a,5a-THPROG
化学名： (3α,5α)-3-Hydroxy-pregnan-20-one
生物活性 for Allopregnanolone
Allopregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.
技术数据 for Allopregnanolone
| 分子量 | 318.49 |
| 公式 | C21H34O2 |
| 储存 | Store at RT |
| CAS Number | 516-54-1 |
| PubChem ID | 92786 |
| InChI Key | AURFZBICLPNKBZ-SYBPFIFISA-N |
| Smiles | C[C@@]12[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Allopregnanolone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 31.85 | 100 | |
| ethanol | 31.85 | 100 |
制备储备液 for Allopregnanolone
以下数据基于产品分子量 318.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.7 mL | 31.4 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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产品说明书 for Allopregnanolone
参考文献 for Allopregnanolone
参考文献是支持产品生物活性的出版物。
Puia et al (1990) Neurosteroids act on recombinant human GABAA receptors. Neuron 4 759 PMID: 2160838
Belelli and Lambert (2005) Neurosteroids: endogenous regulators of the GABAA receptor. Nat.Rev.Neurosci. 6 565 PMID: 15959466
Agis-Balboa et al (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc.Natl.Acad.Sci.USA 103 14602
If you know of a relevant reference for Allopregnanolone, please let us know.
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关键词: Allopregnanolone, Allopregnanolone supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, PAM, 3a,5a-THPROG, Receptors, 3653, Tocris Bioscience
4 篇 Allopregnanolone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Allopregnanolone 的部分引用包括：
Earl (2011) Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J Pharmacol Exp Ther 337 301 PMID: 21262851
Michael et al (2021) Placental endocrine function shapes cerebellar development and social behavior. Nat Neurosci 24 1392-1401 PMID: 34400844
Scott M et al (2020) Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain. Neuropsychopharmacology 45 1263 PMID: 32045935
Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144 PMID: 24062647
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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