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Submit ReviewAlprenolol hydrochloride
说明： β antagonist; also 5-HT1A antagonist
化学名： 1-[(1-Methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-2-propanol hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Alprenolol hydrochloride
Alprenolol hydrochloride is a β-adrenoceptor (β2 > β1 > β3) and 5-HT1A receptor antagonist.
技术数据 for Alprenolol hydrochloride
| 分子量 | 285.81 |
| 公式 | C15H23NO2.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 13707-88-5 |
| PubChem ID | 66368 |
| InChI Key | RRCPAXJDDNWJBI-UHFFFAOYSA-N |
| Smiles | C=CCC1=CC=CC=C1OCC(O)CNC(C)C.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Alprenolol hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 28.58 | 100 |
制备储备液 for Alprenolol hydrochloride
以下数据基于产品分子量 285.81。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.5 mL | 17.49 mL | 34.99 mL |
| 5 mM | 0.7 mL | 3.5 mL | 7 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.5 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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产品说明书 for Alprenolol hydrochloride
参考文献 for Alprenolol hydrochloride
参考文献是支持产品生物活性的出版物。
Blue et al (1990) Antagonist characterization of atypical beta adrenoceptors in guinea pig ileum: blockade by alprenolol and dihydroalprenolol. J.Pharmacol.Exp.Ther. 252 1034 PMID: 1969469
Bjorvatin et al (1992) The 5-HT1A antagonist (-)-alprenolol fails to modify sleep or zimeldine-induced sleep-waking effects in rats. Pharmacol.Biochem.Behav. 42 49 PMID: 1388278
Baker (2005) The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br.J.Pharmacol. 144 317 PMID: 15655528
If you know of a relevant reference for Alprenolol hydrochloride, please let us know.
关键词: Alprenolol hydrochloride, Alprenolol hydrochloride supplier, 5-HT1A, antagonists, β-adrenoceptor, beta-adrenoceptors, b-adrenoceptors, β-adrenergic, beta-adrenergic, b-adrenergic, Serotonin, Receptors, Non-selective, Adrenergic, Beta, 2806, Tocris Bioscience
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Beta2 adrenergic blocker.
By
Anonymous on 01/30/2018
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Acute brain slices
Beta-2 receptor blocker used in brain slices. No effect was found, although not sure if it was due to lack of blockade or lack of involvement of B2R in the observed process
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.