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Alrestatin

Cat. No. 0485 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0485 has been discontinued.

View all Aldose Reductase products.
说明： Aldose reductase inhibitor
化学名： 1,3-Dioxo-1H-benz[d,e]isoquinoline-2(3H)-acetic acid
说明书
引用文献 (3)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Alrestatin

Alrestatin is a specific inhibitor of aldose reductase (IC50 = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.

技术数据 for Alrestatin

分子量 255.23
公式 C14H9NO4
储存 Store at RT
CAS Number 51411-04-2
PubChem ID 2120
InChI Key GCUCIFQCGJIRNT-UHFFFAOYSA-N
Smiles OC(=O)CN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Alrestatin

参考文献是支持产品生物活性的出版物。

Barski et al (1996) The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry 35 14276 PMID: 8916913

Ehrig et al (1994) Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors. Biochemistry 33 7157 PMID: 8003482

Lavrentyev et al (2007) Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells. Circ.Res. 101 455 PMID: 17626897

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关键词: Alrestatin, Alrestatin supplier, Aldose, reductases, inhibitors, inhibits, Carbohydrate, Metabolism, Reductase, 0485, Tocris Bioscience

3 篇 Alrestatin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Alrestatin 的部分引用包括：

Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98 PMID: 22654757

Lavrentyev and Malik (2009) High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. Am J Physiol Heart Circ Physiol 296 H106 PMID: 18978194

Mochin et al (2015) Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. PLoS One 97 55 PMID: 25283348

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