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Submit ReviewAM 1172
说明： Anandamide uptake inhibitor; also FAAH inhibitor and CB receptor partial agonist
化学名： N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxybenzamide
纯度： ≥98% (HPLC)
生物活性 for AM 1172
AM 1172 is a metabolically stable anandamide uptake inhibitor (IC50 = 2.1 - 2.5 μM) and fatty acid amide hydrolase (FAAH) inhibitor (Ki = 3.18 μM). Inhibits N-arachidonylethanolamine (AEA) accumulation (IC50 = 24 μM) and hydrolysis (Ki = 3 μM), and inhibits N-palmitoylethanolamine (PEA) hydrolysis (IC50 = 36 μM) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC50 values are 189 and 271 nM at CB2 and CB1 receptors respectively). FABP inhibitor.
技术数据 for AM 1172
| 分子量 | 409.6 |
| 公式 | C27H39NO2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 251908-92-6 |
| PubChem ID | 10364179 |
| InChI Key | XCWBOAHOJHPWLA-DOFZRALJSA-N |
| Smiles | CCCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCNC(C1=CC=C(O)C=C1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AM 1172
参考文献 for AM 1172
参考文献是支持产品生物活性的出版物。
Kaczocha et al (2006) Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. J.Biol.Chem. 281 9066 PMID: 16461355
Hillard et al (2007) Studies of anandamide accumulation inhibitors in cerebellar granule neurons. J.Mol.Neurosci. 33 18 PMID: 17901541
Fegley et al (2004) Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc.Natl.Acad.Sci.USA 101 8756
Deutsch (2016) A personal retrospective: Elevating Anandamide (AEA) by targeting fatty acid amide hydrolase (FAAH) and the fatty acid binding proteins (FABPs). Front.Pharmacol. 7 370 PMID: 27790143
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关键词: AM 1172, AM 1172 supplier, Anandamide, uptake, inhibitors, inhibits, AMT, FAAH, inhibitor, CB, receptors, partial, agonists, cannabinoid, fatty, acid, amide, hydrolase, neurotransmitter, transporters, AM1172, cb2r, cb1r, FABP, FABPs, binding, protein, Cannabinoid, Transporters, Non-selective, Cannabinoids, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Binding, Proteins, 3381, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
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