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说明： TRPC5 inhibitor
化学名： 2-(2-Bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one
纯度： ≥97% (HPLC)
生物活性 for AM 12
AM 12 is a TRPC5 inhibitor (IC50 = 0.28 μM); Galangin (Cat. No. 6494) derivative. Exhibits some selectivity for TRPC5 over TRPC2, 3 and 4. Inhibits effects of TRPC5 activator (-)-Englerin A, but potentiates effects of physiological activators Sphingosine-1-phosphate (Cat. No.1370) and LPC.
技术数据 for AM 12
| 分子量 | 349.14 |
| 公式 | C15H9BrO5 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 2387510-84-9 |
| PubChem ID | 137553166 |
| InChI Key | OVIAJBSVWWYJSD-UHFFFAOYSA-N |
| Smiles | OC1=CC(O)=C2C(OC(C3=C(Br)C=CC=C3)=C(C2=O)O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AM 12
参考文献 for AM 12
参考文献是支持产品生物活性的出版物。
Naylor et al (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 173 562 PMID: 26565375
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关键词: AM 12, AM 12 supplier, AM12, canonical, transient, receptor, potential, channels, inhibitors, inhibits, TRPC5, TRPC, 6495, Tocris Bioscience
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