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Submit ReviewAM 4668
说明： Potent FFA1 (GPR40) agonist
化学名： (βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid
纯度： ≥98% (HPLC)
生物活性 for AM 4668
AM 4668 is a potent FFA1 (GPR40) agonist (EC50 = 3.6 nM in an IP3 assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable.
技术数据 for AM 4668
| 分子量 | 488.48 |
| 公式 | C24H19F3O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1011531-27-3 |
| PubChem ID | 24897670 |
| InChI Key | BMLGZNVPWRUVNM-IBGZPJMESA-N |
| Smiles | CC1=C(COC2=CC=C(C=C2)[C@H](CC(O)=O)C2=NOC=C2)SC(=N1)C1=CC=C(C=C1)C(F)(F)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AM 4668
参考文献 for AM 4668
参考文献是支持产品生物活性的出版物。
Liu et al (2014) Optimization of GPR40 agonists for type 2 diabetes. ACS Med.Chem.Lett. 5 517 PMID: 24900872
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关键词: AM 4668, AM 4668 supplier, AM4668, free, fatty, acid, receptors, FFA1, FFAR, agonists, agonism, type, 2, diabetes, potent, orally, bioavailable, Free, Fatty, Acid, Receptors, 5789, Tocris Bioscience
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