Ambenonium dichloride

Name: Ambenonium dichloride
Brand: Tocris Bioscience
SKU: 0388

Cat. No. 0388 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0388 has been discontinued.

View all Cholinesterases products.

说明： Cholinesterase inhibitor

化学名： N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride

纯度： ≥99%

说明书

引用文献 (2)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Ambenonium dichloride

Ambenonium dichloride is an extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC₅₀ values are 0.000698 and 8.20 μM at AChE and BChE respectively).

技术数据 for Ambenonium dichloride

分子量	608.48
公式	C₂₈H₄₂Cl₄N₄O₂
储存	Store at RT
纯度	≥99%
CAS Number	115-79-7
PubChem ID	8288
InChI Key	DXUUXWKFVDVHIK-UHFFFAOYSA-N
Smiles	[Cl-].[Cl-].CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=C(Cl)C=CC=C1)CC1=C(Cl)C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Ambenonium dichloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ambenonium dichloride

参考文献是支持产品生物活性的出版物。

Bolognesi et al (2003) Design, synthesis and biological evaluation of amben. derivatives as AChE inhibitors. Farmaco 58 917 PMID: 13679187

Hodge et al (1992) Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 41 937 PMID: 1588924

Lands et al (1958) An investigation of the structure-activity correlations within a series of amben. analogs. J.Pharmacol.Exp.Ther. 123 121 PMID: 13550066

Web (1965) Affinity for benzoquinonium, and amben. derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 102 172 PMID: 5833399

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关键词: Ambenonium dichloride, Ambenonium dichloride supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Non-selective, Muscarinics, Cholinesterases, 0388, Tocris Bioscience

2 篇 Ambenonium dichloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ambenonium dichloride 的部分引用包括：

Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. Int J Mol Sci 112 8124 PMID: 26080439

Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263