AMG 18 hydrochloride

Cat. No. 6166 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective IRE1α inhibitor

化学名： 2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AMG 18 hydrochloride

AMG 18 hydrochloride is a potent and selective IRE1α inhibitor (IC₅₀ values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.

技术数据 for AMG 18 hydrochloride

分子量	637.58
公式	C₃₁H₂₉ClN₆O₃S.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2250019-92-0
PubChem ID	134160238
InChI Key	CNWIPRHGMZTPSB-BOXHHOBZSA-N
Smiles	CC1=C(C2=C(C(NS(=O)(C3=C(C=CC=C3)Cl)=O)=CC=C2)C=C1)OC4=C(C5=NC(N[C@H]6CCCNC6)=NC=C5)C=CC=N4.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AMG 18 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	63.76	100
	DMSO	63.76	100

制备储备液 for AMG 18 hydrochloride

以下数据基于产品分子量 637.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.57 mL	7.84 mL	15.68 mL
5 mM	0.31 mL	1.57 mL	3.14 mL
10 mM	0.16 mL	0.78 mL	1.57 mL
50 mM	0.03 mL	0.16 mL	0.31 mL

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产品说明书 for AMG 18 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AMG 18 hydrochloride

参考文献是支持产品生物活性的出版物。

Harrington et al (2014) Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 6 68 PMID: 25589933

If you know of a relevant reference for AMG 18 hydrochloride, please let us know.

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2 篇 AMG 18 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AMG 18 hydrochloride 的部分引用包括：

Xu et al (2019) The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response. JCI Insight 4 PMID: 30843874

Michael C et al (2022) Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis. JCI Insight 7 PMID: 35167493

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