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Submit ReviewAminoguanidine hydrochloride is a irreversible inhibitor of iNOS that displays some selectivity over eNOS and nNOS. Exhibits antioxidant and radioprotective effects in vivo.
分子量 | 110.55 |
公式 | CH6N4.HCl |
储存 | Store at RT |
CAS Number | 1937-19-5 |
PubChem ID | 16017 |
InChI Key | UBDZFAGVPPMTIT-UHFFFAOYSA-N |
Smiles | Cl.N=C(NN)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Griffiths et al (1993) Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br.J.Pharmacol. 110 963 PMID: 7507781
Huang et al (2009) Aminoguanidine alleviates radiation-induced small-bowel damage through its antioxidant effect. Int.J.Radiat.Oncol.Biol.Phys. 74 237 PMID: 19362242
Laszlo et al (1995) Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. Eur.J.Pharmacol. 272 169 PMID: 7536162
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999
关键词: Aminoguanidine hydrochloride, Aminoguanidine hydrochloride supplier, Irreversible, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, 0787, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Aminoguanidine hydrochloride 的部分引用包括:
Jakubowska et al (2016) Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biol. 6 160149 PMID: 27488376
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