Amiodarone hydrochloride

Name: Amiodarone hydrochloride
Brand: Tocris Bioscience
SKU: 4095

Cat. No. 4095 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4095 has been discontinued.

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说明： Broad spectrum ion channel blocker; antiarrhythmic

化学名： 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (3)

生物活性技术数据说明书参考文献

生物活性 for Amiodarone hydrochloride

Amiodarone hydrochloride is a broad-spectrum ion channel blocker; blocks late I_Na, I_Ca, I_Kr and I_Ks and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca²⁺ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations. Amiodarone depolarizes the resting membrane potential of the triple-negative breast cancer (TNBC) cells and decreases cell migration.

技术数据 for Amiodarone hydrochloride

分子量	681.77
公式	C₂₅H₂₉I₂NO₃.HCl
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	19774-82-4
PubChem ID	29770
InChI Key	ITPDYQOUSLNIHG-UHFFFAOYSA-N
Smiles	CCCCC2=C(C(C3=CC(I)=C(OCCN(CC)CC)C(I)=C3)=O)C1=CC=CC=C1O2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Amiodarone hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Amiodarone hydrochloride

参考文献是支持产品生物活性的出版物。

Antzelevitch et al (2004) Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110 904 PMID: 15302796

di Matola et al (2000) Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism. J.Clin.Endocrin.Metab. 85 4323 PMID: 11095475

Balgi et al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124 PMID: 19771169

Han et al (2009) Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not DA neurons. PLoS One. 4 7155 PMID: 19774075

Payne et al (2021) Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer. EBioMedicine 75 103767 PMID: 34933180

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⚠ WARNING: This product can expose you to chemicals including Amiodarone hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov