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Submit ReviewAmitriptyline hydrochloride
说明： 5-HT and NA reuptake inhibitor (SNRI); also TrkA/B agonist
化学名： 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Amitriptyline hydrochloride
Amitriptyline hydrochloride is an inhibitor of serotonin and noradrenaline uptake; also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.
技术数据 for Amitriptyline hydrochloride
| 分子量 | 313.86 |
| 公式 | C20H23N.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 549-18-8 |
| PubChem ID | 11065 |
| InChI Key | KFYRPLNVJVHZGT-UHFFFAOYSA-N |
| Smiles | CN(CC\C=C2/C3=C(C=CC=C3)CCC1=CC=CC=C12)C.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Amitriptyline hydrochloride
参考文献 for Amitriptyline hydrochloride
参考文献是支持产品生物活性的出版物。
Merck Index 12 85
Sanchez and Hyttel (1999) Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell.Mol.Neurobiol. 19 467 PMID: 10379421
Ghelardini et al (2000) Antinociception induced by amitript. and imipr. is mediated by α2A-adrenoceptors. Jpn.J.Pharmacol. 82 130 PMID: 10877531
Sawynok et al (2001) Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J.Psychiatry Neurosci. 26 21 PMID: 11212590
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1 篇 Amitriptyline hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Amitriptyline hydrochloride 的部分引用包括：
Vladislav et al (2022) Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (Kir 4.1/Kir 5.1) in the cortical collecting duct. Br J Pharmacol 179 2953-2968 PMID: 34904226
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.