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Submit ReviewAMT hydrochloride is a potent, selective and reversible inhibitor of iNOS (IC50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).
分子量 | 166.67 |
公式 | C5H10N2S.HCl |
储存 | Desiccate at +4°C |
CAS Number | 21463-31-0 |
PubChem ID | 2733501 |
InChI Key | HVJCRMIQAMEJNM-UHFFFAOYSA-N |
Smiles | NC1=NCCC(S1)C.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 10 |
以下数据基于产品分子量 166.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 60 mL | 299.99 mL | 599.99 mL |
0.5 mM | 12 mL | 60 mL | 120 mL |
1 mM | 6 mL | 30 mL | 60 mL |
5 mM | 1.2 mL | 6 mL | 12 mL |
参考文献是支持产品生物活性的出版物。
Liao et al (2006) Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes. FASEB J. 20 E1196 PMID: 16877524
Nakane et al (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 47 831 PMID: 7536889
Yu et al (2005) Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes. J.Physiol. 566 327 PMID: 15845578
If you know of a relevant reference for AMT hydrochloride, please let us know.
关键词: AMT hydrochloride, AMT hydrochloride supplier, Potent, selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, 0871, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 AMT hydrochloride 的部分引用包括:
Lee et al (2018) Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways. J Ginseng Res 42 476 PMID: 30337808
Lee et al (2016) Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents. PLoS One 24 67 PMID: 26759704
Wong et al (2017) Role of inducible nitric oxide synthase in endothelium-independent relaxation to RLX in rat aorta. Br J Pharmacol 174 718 PMID: 28138957
Messlinger et al (2000) Involvement of nitric oxide in the modulation of dural arterial blood flow in the rat. Br J Pharmacol 129 1397 PMID: 10742295
Zanardo et al (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A 94 14111 PMID: 9391161
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