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Submit ReviewAMTB hydrochloride
说明： TRPM8 blocker
化学名： N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for AMTB hydrochloride
AMTB hydrochloride is a TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in a rat model (pIC50 = 6.23).
技术数据 for AMTB hydrochloride
| 分子量 | 430.99 |
| 公式 | C23H26N2O2S.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 926023-82-7 |
| PubChem ID | 16095383 |
| InChI Key | UDXGBANGPYONOK-UHFFFAOYSA-N |
| Smiles | O=C(N(CC2=CC=CS2)CCCN)C1=C(OCC3=CC(C)=CC=C3)C=CC=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AMTB hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 43.1 | 100 | |
| DMSO | 43.1 | 100 |
制备储备液 for AMTB hydrochloride
以下数据基于产品分子量 430.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.6 mL | 23.2 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.64 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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产品说明书 for AMTB hydrochloride
参考文献 for AMTB hydrochloride
参考文献是支持产品生物活性的出版物。
Lashinger et al (2008) AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am.J.Physiol.Renal Physiol. 295 F803 PMID: 18562636
If you know of a relevant reference for AMTB hydrochloride, please let us know.
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关键词: AMTB hydrochloride, AMTB hydrochloride supplier, TRPM8, transient, receptor, potential, channels, blockers, TRPM, 3989, Tocris Bioscience
7 篇 AMTB hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AMTB hydrochloride 的部分引用包括：
Liu et al (2015) Menthol suppresses laryngeal C-fiber hypersensitivity to cigarette smoke in a rat model of gastroesophageal reflux disease: the role of TRPM8. J Appl Physiol (1985) 118 635 PMID: 25539933
Sałat and Filipek (2015) Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. Biochem J 16 167 PMID: 25743118
Morgan et al (2015) Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep 35 PMID: 26330615
Mueller-Tribbensee et al (2015) Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. PLoS One 10 e0128242 PMID: 26207981
Laura N et al (2019) Growth at Cold Temperature Increases the Number of Motor Neurons to Optimize Locomotor Function. Curr Biol 29 1787-1799.e5 PMID: 31130453
Diver et al (2019) Structural insights into TRPM8 inhibition and desensitization. Science 365 1434 PMID: 31488702
Melikov et al (2015) Efficient entry of cell-penetrating peptide nona-arginine into adherent cells involves a transient increase in intracellular calcium. Autophagy 471 221 PMID: 26272944
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