Amthamine dihydrobromide

Cat. No. 0668 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Highly selective standard H₂ agonist

化学名： 2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide

纯度： ≥99% (HPLC)

引用文献 (4)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Amthamine dihydrobromide

Amthamine dihydrobromide is a highly selective H₂ agonist, slightly more potent than histamine itself. Only a weak antagonist at H₃ and has no activity at H₁ receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro.

技术数据 for Amthamine dihydrobromide

分子量	319.06
公式	C₆H₁₁N₃S.2HBr
储存	Desiccate at -20°C
纯度	≥99% (HPLC)
CAS Number	142457-00-9
PubChem ID	16218912
InChI Key	XFXNNOPUDSFVJE-UHFFFAOYSA-N
Smiles	Br.Br.CC1=C(CCN)SC(N)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Amthamine dihydrobromide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	31.91	100

制备储备液 for Amthamine dihydrobromide

以下数据基于产品分子量 319.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.67 mL	31.34 mL
5 mM	0.63 mL	3.13 mL	6.27 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Amthamine dihydrobromide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Amthamine dihydrobromide

参考文献是支持产品生物活性的出版物。

Coruzzi et al (1993) The new potent and selective histamine H₂ receptor agonist amthamine as a tool to study gastric secretion. Naunyn Schmiedebergs Arch.Pharmacol. 348 77 PMID: 8377843

Eriks et al (1992) Histamine H₂-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole. J.Med.Chem. 35 3239 PMID: 1507209

Jarajapu et al (2006) Histamine decreases myogenic tone in rat cerebral arteries by H₂-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP. Eur.J.Pharmacol. 547 116 PMID: 16920098

Poli et al (1993) In vitro cardiac pharmacology of the new histamine H₂ receptor agonist amthamine; comparisons with histamine and dimaprit. Agents Actions 40 44 PMID: 8147269

If you know of a relevant reference for Amthamine dihydrobromide, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Histamine H₂ Receptor Agonists

关键词: Amthamine dihydrobromide, Amthamine dihydrobromide supplier, selective, H2, agonists, Receptors, Histamine, histaminergic, 0668, Tocris Bioscience

4 篇 Amthamine dihydrobromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Amthamine dihydrobromide 的部分引用包括：

Saligrama et al (2014) Histamine H₂ receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis. FASEB J 28 1898 PMID: 24371118

Chigaev et al (2011) Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. J Biol Chem 286 20375 PMID: 21515675

Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809

Copsel et al (2011) Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation. J Biol Chem 286 6979 PMID: 21205825

您是否知道使用了 Tocris Amthamine dihydrobromide 的优秀论文？请告知我们.