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Submit ReviewAmthamine dihydrobromide
Discontinued Product
0668 has been discontinued.
View all Histamine H<sub>2</sub> Receptors products.
说明： Highly selective standard H2 agonist
化学名： 2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide
纯度： ≥99% (HPLC)
生物活性 for Amthamine dihydrobromide
Amthamine dihydrobromide is a highly selective H2 agonist, slightly more potent than histamine itself. Only a weak antagonist at H3 and has no activity at H1 receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro.
技术数据 for Amthamine dihydrobromide
| 分子量 | 319.06 |
| 公式 | C6H11N3S.2HBr |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 142457-00-9 |
| PubChem ID | 16218912 |
| InChI Key | XFXNNOPUDSFVJE-UHFFFAOYSA-N |
| Smiles | Br.Br.CC1=C(CCN)SC(N)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Amthamine dihydrobromide
参考文献 for Amthamine dihydrobromide
参考文献是支持产品生物活性的出版物。
Coruzzi et al (1993) The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion. Naunyn Schmiedebergs Arch.Pharmacol. 348 77 PMID: 8377843
Eriks et al (1992) Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole. J.Med.Chem. 35 3239 PMID: 1507209
Jarajapu et al (2006) Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP. Eur.J.Pharmacol. 547 116 PMID: 16920098
Poli et al (1993) In vitro cardiac pharmacology of the new histamine H2 receptor agonist amthamine; comparisons with histamine and dimaprit. Agents Actions 40 44 PMID: 8147269
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关键词: Amthamine dihydrobromide, Amthamine dihydrobromide supplier, selective, H2, agonists, Receptors, Histamine, histaminergic, 0668, Tocris Bioscience
4 篇 Amthamine dihydrobromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Amthamine dihydrobromide 的部分引用包括：
Chigaev et al (2011) Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. J Biol Chem 286 20375 PMID: 21515675
Copsel et al (2011) Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation. J Biol Chem 286 6979 PMID: 21205825
Saligrama et al (2014) Histamine H2 receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis. FASEB J 28 1898 PMID: 24371118
Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.