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ANAVEX 2-73

Cat. No. 5058 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5058 has been discontinued.

说明： Mixed σ1 and muscarinic receptor agonist; exhibits neuroprotective effects
化学名： Tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride
纯度： ≥98% (HPLC)
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生物活性 for ANAVEX 2-73

σ1 agonist (IC50 = 860 nM); also displays affinity for muscarinic M1-M4 receptors (Ki values < 500 nM), but not for σ2 receptors. Exhibits neuroprotective effects, prevents tau hyperphosphorylation, and attenuates scopolamine- and (+)-MK 801-induced learning deficits in a mouse model of amyloid toxicity.

技术数据 for ANAVEX 2-73

分子量 317.85
公式 C19H23NO.HCl
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 195615-84-0
Smiles CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC1)C.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

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参考文献 for ANAVEX 2-73

参考文献是支持产品生物活性的出版物。

Villard et al (2010) Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative. J.Psychopharmacol. 25 1101 PMID: 20829307

Lahmy et al (2013) Blockade of tau hyperphosphorylation and Aβ1-42 generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ1 receptor agonist, in a nontrans Neuropsychopharmacology 38 1706

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关键词: ANAVEX 2-73, ANAVEX 2-73 supplier, ANAVEX2-73, σ1, sigma1, muscarinic, M1, M2, M3, M4, receptors, agonists, Alzheimers, disease, AD, anti-amnesic, neuroprotective, neuroprotectants, Sigma1, Receptors, Non-selective, Muscarinics, 5058, Tocris Bioscience

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