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Angiotensin A

Cat. No. 5335 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent endogenous vasoconstrictor peptide - derivative of angiotensin II (Cat. No. 1158)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Angiotensin A

Angiotensin A is a potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Elicits pressor and renal vasoconstrictor effects in rodents via the AT1 receptor; inhibited by Candesartan (Cat. No. 4791) but not by AT2 receptor ligands in vivo. Displays a similar affinity for AT1 and AT2 receptors as angiotensin II in vitro (Ki values are 1.6 and 2.3 nM at AT1 and AT2 receptors); also increases inositol phosphate accumulation with a similar potency to Ang II (EC50 = 6.7 nM).

技术数据 for Angiotensin A

分子量 1002.18
公式 C49H71N13O10
序列 ARVYIHPF
储存 Store at -20°C
CAS Number 51833-76-2
PubChem ID 91691124
InChI Key CHCOFDZSJYMQMX-NOQNJSOHSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Angiotensin A

参考文献是支持产品生物活性的出版物。

Yang et al (2011) Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent. Hypertension 57 956 PMID: 21464395

Coutinho et al (2013) Cardiovascular effects of angiotensin A: A novel peptide of the renin-angiotensin system. J.Renin Angiotensin Aldosterone Syst. 15 480 PMID: 23386282

Villela et al (2014) Alamandine: a new member of the angiotensin family. Curr.Opin.Nephrol.Hypertens. 23 130 PMID: 24389733

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关键词: Angiotensin A, Angiotensin A supplier, Angiotensin, A, II, receptors, potent, endogenous, vasoconstrictor, peptide, AT1, AT2, agonists, Non-selective, AT, Receptors, 5335, Tocris Bioscience

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