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Submit ReviewApelin-17 (human, bovine) is an endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).
分子量 | 2138.56 |
公式 | C96H156N34O20S |
序列 | KFRRQRPRLSHKGPMPF |
储存 | Store at -20°C |
纯度 | ≥95% (HPLC) |
CAS Number | 217082-57-0 |
PubChem ID | 16130452 |
InChI Key | SVWSKJCJNAIKNH-MJZUAXFLSA-N |
Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Medhurst et al (2003) Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J.Neurochem. 84 1162 PMID: 12603839
Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comms. 251 471
De Mota et al (2004) Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc.Natl.Acad.Sci. USA 101 10464
关键词: Apelin-17 (human, bovine), Apelin-17 (human, bovine) supplier, Endogenous, APJ, receptor, agonists, Receptors, Apelin, adipokines, K17F, Prepro-61-77-Apelin, 3007, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Apelin-17 (human, bovine) 的部分引用包括:
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
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