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说明： Potent histone deacetylase inhibitor
化学名： Cyclo[(2S)-2-Amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
纯度： ≥98% (HPLC)
生物活性 for Apicidin
Potent histone deacetylase (HDAC) inhibitor (IC50 = 0.7 nM in an enzyme activity assay). Antiangiogenic and anti-invasive; blocks proliferation of human stomach and breast cancer cells. Induces apoptosis and autophagy in human oral squamous carcinoma cells.
技术数据 for Apicidin
| 分子量 | 623.78 |
| 公式 | C34H49N5O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 183506-66-3 |
| PubChem ID | 44593387 |
| InChI Key | JWOGUUIOCYMBPV-VWIQTCEGSA-N |
| Smiles | CON2C1=CC=CC=C1C(C[C@@H](C(N[C@@H]([C@H](C)CC)C3=O)=O)NC([C@H](CCCCCC(CC)=O)NC([C@]4([H])N3CCCC4)=O)=O)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Apicidin
参考文献 for Apicidin
参考文献是支持产品生物活性的出版物。
Han et al (2000) Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 60 6068 PMID: 11085529
Darkin-Rattray et al (1996) Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc.Natl.Acad.Sci. 93 13143 PMID: 8917558
Ahn et al (2011) Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells. Oral Oncol. 47 1032 PMID: 21856210
Kim et al (2004) Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials. Biochem.Biophys.Res.Comm. 19 964 PMID: 14985106
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关键词: Apicidin, Apicidin supplier, potent, histone, deacetylases, HDACs, inhibitors, inhibits, antiangiogenics, anti-invasive, cancer, apoptosis, autophagy, Apoptosis, Inducers, Autophagy, Non-selective, Non-Selective, 4846, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.