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Submit ReviewAR-M 1000390 hydrochloride
Discontinued Product
4335 has been discontinued.
说明： Low-internalizing δ agonist
化学名： N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)-benzamide hydrochloride
纯度： ≥97% (HPLC)
生物活性 for AR-M 1000390 hydrochloride
AR-M 1000390 hydrochloride is a non-peptidic, low-internalizing δ-selective opioid receptor agonist; derivative of SNC 80 (Cat. No. 0764). Does not trigger acute desensitization of the analgesic response; reduces CFA-induced hyperalgesia. Brain penetrant following systemic administration.
技术数据 for AR-M 1000390 hydrochloride
| 分子量 | 384.94 |
| 公式 | C23H28N2O.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 209808-47-9 |
| PubChem ID | 76848958 |
| InChI Key | OTXTZCLQEGSAMW-UHFFFAOYSA-N |
| Smiles | O=C(N(CC)CC)C1=CC=C(/C(C3=CC=CC=C3)=C2\CCNCC2)C=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AR-M 1000390 hydrochloride
参考文献 for AR-M 1000390 hydrochloride
参考文献是支持产品生物活性的出版物。
Marie et al (2003) Pharmacological characterization of AR-M1000390 at human opioid delta receptors. Life Sci. 73 1691 PMID: 12875901
Pradhan et al (2010) Ligand-directed trafficking of the δ-opioid receptor in vivo: Two paths toward analgesic tolerance. J.Neurosci. 30 16459 PMID: 21147985
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关键词: AR-M 1000390 hydrochloride, AR-M 1000390 hydrochloride supplier, AR-M1000390, HCl, delta, opioids, δ-opioid, receptors, agonists, Delta, Opioid, Receptors, 4335, Tocris Bioscience
3 篇 AR-M 1000390 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AR-M 1000390 hydrochloride 的部分引用包括：
Stoeber et al (2018) A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron 98 963 PMID: 29754753
Francesco Luigi et al (2023) Subcellular location defines GPCR signal transduction. Sci Adv 9 eadf6059 PMID: 37075112
Anika et al (2020) Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies. Sci Rep 10 8585 PMID: 32444688
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