主页 / 药理学 / GPCRs / 7-TM Receptors / Adrenergic Receptors / Adrenergic α2 Receptors / Adrenergic α2 Receptor Antagonists / ARC 239 dihydrochloride

ARC 239 dihydrochloride

Cat. No. 0928 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： α2B antagonist
化学名： 2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ARC 239 dihydrochloride

ARC 239 dihydrochloride is a selective α2B adrenoceptor antagonist (pKD values are 8.8, 6.7 and 6.4 at α2B, α2A, and α2D receptors respectively).

许可信息

Sold with the permission of Boehringer Ingelheim GmbH

技术数据 for ARC 239 dihydrochloride

分子量 480.43
公式 C24H29N3O3.2HCl
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 55974-42-0
PubChem ID 10345075
InChI Key SAJKHRHHDGSJEZ-UHFFFAOYSA-N
Smiles Cl.Cl.COC1=CC=CC=C1N1CCN(CCN2C(=O)C3=C(C=CC=C3)C(C)(C)C2=O)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ARC 239 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 48.04 100

制备储备液 for ARC 239 dihydrochloride

以下数据基于产品分子量 480.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.41 mL 20.81 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for ARC 239 dihydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ARC 239 dihydrochloride

参考文献是支持产品生物活性的出版物。

Bylund et al (1988) Alpha-2A and alpha-2B adrenergic subtypes: antagonist binding in tissues and cell lines containing only one subtype. J.Pharmacol.Exp.Ther. 245 600 PMID: 2835476

Fuder and Selback (1993) Characterisation of sensory neurotransmission and its inhibition via α2B-adrenoceptors and via non-α2 adrenoceptors in rabbit iris. Naunyn Schmiedebergs Arch.Pharmacol. 347 394 PMID: 7685502

If you know of a relevant reference for ARC 239 dihydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Adrenergic α2 Receptor Antagonists

关键词: ARC 239 dihydrochloride, ARC 239 dihydrochloride supplier, α2B-adrenoceptor, alpha2B-adrenoceptor, α2b-adrenergic, alpha2b-adrenergic, a2b-adrenoceptor, a2b-adrenergic, antagonists, Receptors, ARC239, dihydrochloride, Adrenergic, Alpha-2, 0928, Tocris Bioscience

1 篇 ARC 239 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ARC 239 dihydrochloride 的部分引用包括：

Kahn et al (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med 8 511 PMID: 27138566

您是否知道使用了 Tocris ARC 239 dihydrochloride 的优秀论文？ 请告知我们.

ARC 239 dihydrochloride 的评论

目前没有该产品的评论。 Be the first to review ARC 239 dihydrochloride and earn rewards!

Have you used ARC 239 dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.