[Arg¹⁴,Lys¹⁵]Nociceptin

Name: [Arg 14 ,Lys 15 ]Nociceptin
Brand: Tocris Bioscience
SKU: 1590

Cat. No. 1590 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1590 has been discontinued.

View all NOP Receptors products.

说明： Highly potent and selective NOP agonist

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for [Arg¹⁴,Lys¹⁵]Nociceptin

[Arg¹⁴,Lys¹⁵]Nociceptin is a highly potent and selective NOP receptor agonist (EC₅₀ = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC₅₀ values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.

技术数据 for [Arg¹⁴,Lys¹⁵]Nociceptin

分子量	1909.18
公式	C₈₂H₁₃₇N₃₁O₂₂
序列	FGGFTGARKSARKRKNQ
储存	Desiccate at -20°C
CAS Number	236098-40-1
PubChem ID	16143911
InChI Key	VULLMZOQBGUKAT-VUXBHJHDSA-N
Smiles	[H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for [Arg¹⁴,Lys¹⁵]Nociceptin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for [Arg¹⁴,Lys¹⁵]Nociceptin

参考文献是支持产品生物活性的出版物。

Calo et al (2002) Pharmacological profile of nociceptin/orphanin FQ receptors. Clin.Exp.Pharmacol.Physiol. 29 223 PMID: 11906488

Okada et al (2000) Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem.Biophys.Res.Commun. 278 493 PMID: 11097863

Rizzi et al (2002) [Arg¹⁴,Lys¹⁵]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J.Pharmacol.Exp.Ther. 300 57 PMID: 11752097

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关键词: [Arg14,Lys15]-Nociceptin, [Arg14,Lys15]-Nociceptin supplier, potent, selective, NOP, agonists, Nociceptin, Receptors, ORL1, OP4, Opioid, 1590, Tocris Bioscience

1 篇 [Arg¹⁴,Lys¹⁵]Nociceptin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 [Arg¹⁴,Lys¹⁵]Nociceptin 的部分引用包括：

Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132 PMID: 14662736