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ARN 11391

Cat. No. 7909 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potentiator of the IP3-gated calcium channel ITPR1
化学名： 2-Ethyl-4,5,6,7-tetrahydro-N-[2-[(tetrahydro-2H-pyran-2-yl)methoxy]phenyl]-2H-indazole-3-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ARN 11391

ARN 11391 is a potentiator of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1). It amplifies intracellular calcium ion signaling by acting directly on ITPR1. ARN 11391 also potentiates calcium signaling in cells expressing mutant ITPR1 which is associated with SCA29, a form of spinocerebellar ataxia.

技术数据 for ARN 11391

分子量 383.49
公式 C22H29N3O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1214569-31-9
PubChem ID 46969526
InChI Key WEHYVOUAIUTKKA-UHFFFAOYSA-N
Smiles O=C(C1=C2C(CCCC2)=NN1CC)NC3=C(OCC4OCCCC4)C=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ARN 11391

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.35 100
ethanol 38.35 100

制备储备液 for ARN 11391

以下数据基于产品分子量 383.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
10 mM 0.26 mL 1.3 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for ARN 11391

参考文献是支持产品生物活性的出版物。

Genovese et al (2022) Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening. PNAS Nexus 2 pgac288 PMID: 36712939

If you know of a relevant reference for ARN 11391, please let us know.

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关键词: ARN 11391, ARN 11391 supplier, ARN11391, potentiator, calcium, ion, signaling, SCA29, spinocerebellar, ataxia, IP3, receptor, receptors, channel, channels, Receptors, 7909, Tocris Bioscience

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