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Artemether

Cat. No. 6818 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Antimalarial; also inhibits neuroinflammation
化学名： (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Artemether

Artemether is an antimalarial. Prevents cerebral malaria in Plasmodium berghei infected mice. Exhibits synergistic effects with Methylene Blue (Cat. No. 3213) against P. falciparum in vitro. Inhibits neuroinflammation in neuronal/microglial cell co-cultures via induction of Nrf2 expression.

技术数据 for Artemether

分子量 298.37
公式 C16H26O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 71963-77-4
PubChem ID 68911
Smiles [H][C@@]12CC[C@H]([C@@]3(CC[C@]4(OO[C@@]13[C@](O[C@@H]([C@@H]2C)OC)(O4)[H])C)[H])C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Artemether

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.84 100
ethanol 29.84 100

制备储备液 for Artemether

以下数据基于产品分子量 298.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.76 mL 33.52 mL
5 mM 0.67 mL 3.35 mL 6.7 mL
10 mM 0.34 mL 1.68 mL 3.35 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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参考文献 for Artemether

参考文献是支持产品生物活性的出版物。

Okorji et al (2015) Antimalarial drug artem. inhibits neuroinflammation in BV2 microglia through Nrf2-dependent mechanisms. Mol.Neurobiol. 53 PMID: 26607631

Prada et al (1996) Upregulation of reactive oxygen and nitrogen intermediates in Plasmodium berghei infected mice after rescue therapy with chloroquine or artem. J.Antimicrob.Chemother. 38 95 PMID: 8858461

Akoachere et al (2005) In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins. Antimicrob.Agents Chemother. 49 4592 PMID: 16251300

If you know of a relevant reference for Artemether, please let us know.

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关键词: Artemether, Artemether supplier, antimalarials, malaria, plasmodium, neuroinflammation, inhibits, inhibitors, Antimalarials, 6818, Tocris Bioscience

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