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说明： Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
化学名： 4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid
纯度： ≥98% (HPLC)
生物活性 for Artesunate
Artesunate suppresses ROS-induced activation of the NLRP3 inflammasome. Arrests cell cycle in the G2/M phase and sensitizes human renal cell carcinoma (RCC) cell lines to sorafenib in vitro. Aretesumate is an antimalarial (Plasmodium).
技术数据 for Artesunate
| 分子量 | 384.42 |
| 公式 | C19H28O8 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 88495-63-0 |
| PubChem ID | 6917864 |
| InChI Key | FIHJKUPKCHIPAT-AHIGJZGOSA-N |
| Smiles | [H][C@@]12CC[C@H]([C@@]3(CC[C@]4(OO[C@@]13[C@](O[C@H]([C@@H]2C)OC(CCC(O)=O)=O)(O4)[H])C)[H])C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Artesunate
参考文献 for Artesunate
参考文献是支持产品生物活性的出版物。
Meshnick et al (2002) Artemisinin: mechanisms of action, resistance and toxicity. In.J.Parasitol. 32 1655 PMID: 12435450
Jeong et al (2015) Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis. Oncotarget. 6 33046 PMID: 26426994
Liu et al (2018) Artesunate inhibits renal ischemia-reperfusion-mediated remote lung inflammation through attenuating ROS-induced activation of NLRP3 inflammasome. Inflammation 41 1546 PMID: 29730819
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关键词: Artesunate, Artesunate supplier, malaria, antimalarial, ROS, inhibitors, inhibits, NLRP3, inflammasome, G2/M, phase, arrest, Plasmodium, falciparum, Inflammasomes, Cell, Cycle, Inhibitors, Antimalarials, 6827, Tocris Bioscience
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