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AS 19

Cat. No. 1968 4 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent 5-HT7 agonist
化学名： (2S)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AS 19

AS 19 is a potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo. AS 19 also promotes melanin synthesis in B16F10 murine melanoma cells.

技术数据 for AS 19

分子量 283.41
公式 C18H25N3
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 1000578-26-6
PubChem ID 23642275
InChI Key BTTOYOKCLDAHHO-HNNXBMFYSA-N
Smiles CC1=C(C2=CC=CC3=C2CC[C@H](N(C)C)C3)C(C)=NN1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AS 19

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 28.34 100
DMSO 28.34 100

制备储备液 for AS 19

以下数据基于产品分子量 283.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.64 mL 35.28 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.76 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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产品说明书 for AS 19

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for AS 19

参考文献是支持产品生物活性的出版物。

Perez-Garcia and Meneses (2005) Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav.Brain Res. 163 136 PMID: 15936093

Perez-Garcia et al (2006) An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation. Behav.Brain Res. 169 83 PMID: 16480781

Horiguchi et al (2011) The role of 5-hydroxytrpytamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. J.Pharmacol.Exp.Ther. 338 605 PMID: 21558435

Tang et al (2023) Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways. FASEB J. 37 e22893 PMID: 36961387

If you know of a relevant reference for AS 19, please let us know.

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关键词: AS 19, AS 19 supplier, potent, 5-HT7, agonists, serotonin, receptors, 5-Hydroxytryptamine, agonist, AS19, melanogenesis, melanin, synthesis, anti-amnesic, Receptors, 1968, Tocris Bioscience

4 篇 AS 19 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AS 19 的部分引用包括：

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Neuropsychopharmacology 3 e00103 PMID: 25692021

Tang et al (2023) Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways FASEB J 37 e22893

Domínguez-Soto (2017) Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis. Sci Rep 7 14761 PMID: 29116249

Majeed et al (2016) Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast 2016 7291438 PMID: 26989517

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AS 19 的评论

平均评分: 5 (Based on 1 Review.)

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5-HT has a potential for relaxant.
By Anonymous on 02/18/2020
分析类型： In Vivo
种属： Rat

AS19 (5-HT7) and concentration(0.0001 mol/L)

PMID: 25692021
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