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ASB 14780

Cat. No. 6316 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor; active in vivo; orally bioavailable
化学名： 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid tris salt
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ASB 14780

ASB 14780 is a potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor (IC50 = 20 nM). Selective for cPLA2α over secreted PLA2α (sPLA2α; exhibits no inhibition at 10 μM). Inhibits cPLA2α-dependent inflammatory responses in vitro in guinea pig and human whole-blood assays. Improves diet-induced liver injury and CCl4-induced hepatic fibrosis in vivo. Orally bioavailable.

技术数据 for ASB 14780

分子量 582.7
公式 C31H27NO3.C4H11NO3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1069046-00-9
PubChem ID 68519061
InChI Key MBPXGBINIINSEU-UHFFFAOYSA-N
Smiles NC(CO)(CO)CO.OC(CCC1=CC=C2N(C3=CC=C(C=C3)OC4=CC=CC=C4)C=C(C2=C1)CCC5=CC=CC=C5)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ASB 14780

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 58.27 100

制备储备液 for ASB 14780

以下数据基于产品分子量 582.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.72 mL 8.58 mL 17.16 mL
5 mM 0.34 mL 1.72 mL 3.43 mL
10 mM 0.17 mL 0.86 mL 1.72 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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参考文献 for ASB 14780

参考文献是支持产品生物活性的出版物。

Kanai et al (2016) ASB14780, an orally active inhibitor of group IVA phospholipase A2, is a pharmacotherapeutic candidate for nonalcoholic fatty liver disease. J.Pharmacol.Exp.Ther. 356 604 PMID: 26699145

Tomoo et al (2014) Design, synthesis, and biological evaluation of 3-(1-aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α. J.Med.Chem. 57 7244 PMID: 25102418

If you know of a relevant reference for ASB 14780, please let us know.

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关键词: ASB 14780, ASB 14780 supplier, ASB14780, AS_B, 14780, potent, selective, cytosolic, group, IVA, phospholipase, A2, alpha, cPLA2a, cPLA2, alfa, inhibitors, inhibits, liver, disease, orally, active, in, vivo, Phospholipases, 6316, Tocris Bioscience

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