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ASP 7663

Cat. No. 5178 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective TRPA1 activator
化学名： (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ASP 7663

ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). Displays little or no affinity at more than 60 other related receptors, channels and enzymes. Stimulates 5-HT release from QGP-1 cells. Exhibits an abdominal analgesic effect in vivo. Orally bioavailable.

技术数据 for ASP 7663

分子量 263.26
公式 C14H14FNO3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1190217-35-6
PubChem ID 44232532
InChI Key RCVZUIGCNAAMIC-UXBLZVDNSA-N
Smiles O=C2/C(C1=CC=CC(F)=C1N2CC(C)C)=C/C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ASP 7663

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.33 100
ethanol 26.33 100

制备储备液 for ASP 7663

以下数据基于产品分子量 263.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.8 mL 18.99 mL 37.99 mL
5 mM 0.76 mL 3.8 mL 7.6 mL
10 mM 0.38 mL 1.9 mL 3.8 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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产品说明书 for ASP 7663

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ASP 7663

参考文献是支持产品生物活性的出版物。

Kojima et al (2014) Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur.J.Pharmacol. 723 288 PMID: 24291101

If you know of a relevant reference for ASP 7663, please let us know.

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关键词: ASP 7663, ASP 7663 supplier, ASP7663, transient, receptor, potential, ankyrin, 1, selective, TRPA1, activators, activates, anticonstipation, abdominal, analgesics, 5HT, 5178, Tocris Bioscience

2 篇 ASP 7663 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ASP 7663 的部分引用包括：

Ko et al (2019) A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep 9 2430 PMID: 30787340

Blaha et al (2019) Bladder Dysfunction in an Obese Zucker Rat: The Role of TRPA1 Channels, Oxidative Stress, and Hydrogen Sulfide. Oxid Med Cell Longev 2019 5641645 PMID: 31531184

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