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Submit ReviewAT 1015
说明： Long-acting 5-HT2A antagonist
化学名： N-[2-[4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-piperidinyl]ethyl]-1-formyl-4-piperidinecarboxamide hydrochloride
纯度： ≥97% (HPLC)
生物活性 for AT 1015
AT 1015 is a long-acting 5-HT2A receptor antagonist; inhibits vasoconstriction and blocks platelet aggregation. Prolongs clotting time in a rat model of thrombus formation; ameliorates laurate-induced peripheral vascular lesions in rodents.
技术数据 for AT 1015
| 分子量 | 492.05 |
| 公式 | C29H33N3O2.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 190508-50-0 |
| PubChem ID | 9805663 |
| InChI Key | YZHGXYNLMHGNJZ-UHFFFAOYSA-N |
| Smiles | O=C(C5CCN(C=O)CC5)NCCN(CC3)CC/C3=C1C(C=CC=C4)=C4C=CC2=C\1C=CC=C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AT 1015
参考文献 for AT 1015
参考文献是支持产品生物活性的出版物。
Rashid et al (2001) Assessment of affinity and dissociation ability of a newly synthesized 5-HT2 antagonist, AT-1015: comparison with other 5-HT2 antagonists. Jpn.J.Pharmacol. 87 189 PMID: 11885967
Kihara et al (2000) AT-1015, a novel serotonin (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2A receptors and prevents the laurate-induced peripheral vascular lesions in rats. J.Cardiovasc.Pharmacol. 35 523 PMID: 10774780
Kihara et al (2001) Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time. Eur.J.Pharmacol. 433 157 PMID: 11755147
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关键词: AT 1015, AT 1015 supplier, AT1015, supplier, serotonin, 5-HT2, receptor, antagonists, vasoconstriction, antithrombotics, antiplatelet, aggregation, 5-HT2A, Receptors, 4468, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.