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Submit ReviewATI 2341
说明： CXCR4 allosteric agonist
纯度： ≥95% (HPLC)
生物活性 for ATI 2341
ATI 2341 is a CXCR4 allosteric agonist (EC50 = 194 nM). Induces chemotaxis in CXCR4-expressing cells in vitro. Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo. Exhibits biased signaling towards Gi proteins over G13 and β-arrestin.
技术数据 for ATI 2341
| 分子量 | 2256.82 |
| 公式 | C104H178N26O25S2 |
| 序列 |
MGYQKKLRSMTDKYRL (Modification: Met-1 = N-terminal Palmitoyl) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1337878-62-2 |
| PubChem ID | 101961246 |
| InChI Key | YMLOFEANRZSEGQ-QNHYGVTPSA-N |
| Smiles | CCCCCCCCCCCCCCCC(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ATI 2341
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for ATI 2341
参考文献 for ATI 2341
参考文献是支持产品生物活性的出版物。
Tchernychev et al (2010) Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc.Natl.Acad.Sci.U.S.A. 107 22255 PMID: 21139054
Planesas et al (2015) Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. J.Mol.Graph Model. 60 1 PMID: 26080355
Quoyer et al (2013) Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc.Natl.Acad.Sci.U.S.A. 110 E5088 PMID: 24309376
If you know of a relevant reference for ATI 2341, please let us know.
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关键词: ATI 2341, ATI 2341 supplier, CXCR4, allosteric, agonists, polymorphonuclear, neutrophils, PMNs, hematopoietic, stem, progenitor, cells, HSPCs, biased, signaling, Chemokine, CXC, Receptors, 5795, Tocris Bioscience
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