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Submit ReviewAtorvastatin hemicalcium salt
说明： Potent HMG-CoA reductase inhibitor
别名： Lipitor
化学名： (R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt
纯度： ≥99% (HPLC)
生物活性 for Atorvastatin hemicalcium salt
Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for Atorvastatin hemicalcium salt
| 分子量 | 577.67 |
| 公式 | C33H34FN2O5.½Ca |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 134523-03-8 |
| PubChem ID | 60822 |
| InChI Key | FQCKMBLVYCEXJB-MNSAWQCASA-L |
| Smiles | [Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Atorvastatin hemicalcium salt
参考文献 for Atorvastatin hemicalcium salt
参考文献是支持产品生物活性的出版物。
Istvan et al (2001) Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292 1160 PMID: 11349148
Vaughan et al (2004) Update on STAT: 2003. Circulation 110 886 PMID: 15313959
Santodomingo-Garzon et al (2006) AtoVas inhibits inflammatory hypernociception. Br.J.Pharmacol. 149 14 PMID: 16865092
Turner et al (2007) Comparison of the efficacies of five different STAT on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 50 458 PMID: 18049315
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关键词: Atorvastatin hemicalcium salt, Atorvastatin hemicalcium salt supplier, HMG-CoA, reductases, inhibitors, inhibits, cholesterol, biosynthesis, LDL, Pfizer, statins, Lipitor, Reductase, 3776, Tocris Bioscience
2 篇 Atorvastatin hemicalcium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Atorvastatin hemicalcium salt 的部分引用包括：
Nowak et al (2019) AtoVas and Conditioned Media from AtoVas-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show Proangiogenic Activity In Vitro but Not In Vivo. Mediators Inflamm 2019 1868170 PMID: 31396016
Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942
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Atorvastatin effect as Rho inhibitor.
By
Anonymous on 03/26/2018
分析类型： In Vitro
种属： Other
细胞系/组织： chondrocyte
used as alternative to simvastatin
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