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Submit ReviewAUNP 12
说明： Peptide inhibitor of the PD-1 signaling pathway
纯度： ≥95% (HPLC)
生物活性 for AUNP 12
AUNP 12 is an immune checkpoint modulator targeting the programmed cell death 1 (PD-1) signaling pathway. It inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2. In the mouse splenocyte assay system, AUNP 12 rescues proliferation (EC50 values are 17 and 16 nM for PD-L1 and PD-L2, respectively) and enhances T-cell activity by restoring IFNγ release inhibited by PD-L1 and PD-L2 (EC50 values are 49 nM and 51 nM respectively). In a mouse Renca renal cell carcinoma model, AUNP 12 shows an additive antitumor effect when combined with Cyclophosphamide (Cat. No. 4091).
技术数据 for AUNP 12
| 分子量 | 3261.56 |
| 公式 | C142H226N40O48 |
| 序列 |
SNTSESFKFRVTQLAPKAQIKE SNTSESF* (Modifications: Amide bridge= 8-7*, Glu-22 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1353563-85-5 |
| PubChem ID | 154701623 |
| InChI Key | ZBJUUYIGBAQYBN-QKLNNLIKSA-N |
| Smiles | OC(CC[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H]([C@H](CC)C)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CC(N)=O)=O)[C@@H](C)O)=O)CO)=O)=O)=O)=O)CCCCNC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC([C@H]([C@@H](C)O)NC([C@H](CC(N)=O)NC([C@H](CO)N)=O)=O)=O)=O)CCC(O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)CCCNC(N)=N)=O)C(C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CC(C)C)=O)C)=O)=O)=O)C)=O)CCC(N)=O)=O)=O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AUNP 12
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for AUNP 12
参考文献 for AUNP 12
参考文献是支持产品生物活性的出版物。
Omstead et al (2022) CSF-1R inhibitor, pexidartinib, sensitizes esophageal adenocarcinoma to PD-1 immune checkpoint blockade in a rat model. Carcinogenesis 43 842 PMID: 35552655
Sasikumar et al (2019) A rationally designed peptide antagonist of the PD-1 signaling pathway as an immunomodulatory agent for cancer therapy. Mol.Cancer Ther. 18 1081 PMID: 31015307
Zhan et al (2016) From monoclonal antibodies to small molecules: the development of inhibitors targeting the PD-1/PD-L1 pathway. Drug Discov.Today 21 1027 PMID: 27094104
If you know of a relevant reference for AUNP 12, please let us know.
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关键词: AUNP 12, AUNP 12 supplier, AUNP12, immune, checkpoint, programmed, cell, death, 1, PD-1, PD-L1, PD-L2, IFN, gamma, Interferon, Other, Apoptosis, Immune, Checkpoints, 7831, Tocris Bioscience
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