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说明： Thioredoxin reductase inhibitor; induces MPT
化学名： 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate
生物活性 for Auranofin
Auranofin is an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Thought to induce the mitochondrial permeability transition via inhibition of mitochondrial TrxR. Also exhibits anti-inflammatory and immunosuppressive activities; inhibits 5-lipoxygenase at high concentrations and stimulates LTA hydrolase at low concentrations. Also inhibits SARS-CoV-2 infection in Huh7 cell line (IC50 = 1.4 μM)
技术数据 for Auranofin
| 分子量 | 678.48 |
| 公式 | C20H34AuO9PS |
| 储存 | Store at RT |
| CAS Number | 34031-32-8 |
| PubChem ID | 6918453 |
| InChI Key | AUJRCFUBUPVWSZ-XTZHGVARSA-M |
| Smiles | CCP(CC)(CC)=[Au]S[C@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Auranofin
参考文献 for Auranofin
参考文献是支持产品生物活性的出版物。
Kim et al (2007) Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3. Immunology 122 607 PMID: 17645497
Rigobello et al (2002) Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative. Br.J.Pharmacol. 136 1162 PMID: 12163349
Gromer et al (1998) Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds. J.Biol.Chem. 273 20096 PMID: 9685351
Betts et al (1990) Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophils. Biochem.Pharmacol. 39 1233 PMID: 2157444
Rothan et al (2020) The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells. Virology 547 7 PMID: 32442105
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关键词: Auranofin, Auranofin supplier, antirheumatic, antiarthritic, arthritis, mitochondrial, permeability, pore, transition, mpt, inducers, anti-inflammatory, anti-inflammatories, immunosuppressive, immunosuppressants, thioredoxin, reductase, TrxR, inhibitors, inhibits, SARS-CoV-2, infection, MPTP, Thioredoxin, Reductases, COVID-19, Coronavirus, 4600, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Auranofin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
1 篇 Auranofin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Auranofin 的部分引用包括：
Tsai et al (2015) Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem 290 21845 PMID: 26187466
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