主页 / 细胞生物学 / Signal Transduction / Hedgehog Signaling / Hedgehog Signaling Inhibitors / AY 9944 dihydrochloride

AY 9944 dihydrochloride

Cat. No. 1639 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of Hedgehog (Hh) signaling. Inhibits Δ7-dehydrocholesterol reductase
化学名： trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (4)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AY 9944 dihydrochloride

AY 9944 dihydrochloride is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo.

技术数据 for AY 9944 dihydrochloride

分子量 464.3
公式 C22H28Cl2N2.2HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 366-93-8
PubChem ID 9954082
InChI Key GZFYZYBWLCYBMI-MYZJJQSMSA-N
Smiles ClC(C=CC=C3)=C3CNC[C@H]1CC[C@H](CNCC2=C(Cl)C=CC=C2)CC1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AY 9944 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 23.21 50
DMSO 2.32 5

制备储备液 for AY 9944 dihydrochloride

以下数据基于产品分子量 464.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.31 mL 21.54 mL 43.08 mL
2.5 mM 0.86 mL 4.31 mL 8.62 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
25 mM 0.09 mL 0.43 mL 0.86 mL

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产品说明书 for AY 9944 dihydrochloride

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参考文献 for AY 9944 dihydrochloride

参考文献是支持产品生物活性的出版物。

Cooper et al (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280 1603 PMID: 9616123

Incardona and Eaton (2000) Cholesterol in signal transduction. Curr.Opin.Cell Biol. 12 193 PMID: 10712926

Kraml et al (1964) Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944. Biochem.Biophys.Res.Commun. 15 455 PMID: 4283982

Moebius et al (1998) Molecular cloning and expression of the human Δ7-sterol reductase. Proc.Natl.Acad.Sci.U.S.A. 95 1899 PMID: 9465114

If you know of a relevant reference for AY 9944 dihydrochloride, please let us know.

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关键词: AY 9944 dihydrochloride, AY 9944 dihydrochloride supplier, inhibitors, inhibits, hedgehog, Hh, signaling, Δ7-dehydrocholesterol, Delta7-dehydrocholesterol, reductases, Signalling, DHCR, Reductase, Reductases, AY9944, dihydrochloride, Hedgehog, Signaling, Delta-Dehydrocholesterol, 1639, Tocris Bioscience

1 篇 AY 9944 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AY 9944 dihydrochloride 的部分引用包括：

Kant et al (2019) Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell 24 363 PMID: 30686764

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