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Submit ReviewAZ 12080282 dihydrochloride
说明： Inhibitor of Hedgehog (Hh) signaling
化学名： N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for AZ 12080282 dihydrochloride
AZ 12080282 dihydrochloride is an inhibitor of Hedgehog (Hh) signaling (IC50 <0.012 μM in a firefly reporter assay against the Hh pathway). Shown to displace cyclopamine in HeLa cells expressing Smoothened. Exhibits selectivity against p38α. Orally bioavailable.
许可信息
Sold with the permission of AstraZeneca UK Ltd.
技术数据 for AZ 12080282 dihydrochloride
| 分子量 | 457.35 |
| 公式 | C23H20N4O2.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 78243727 |
| InChI Key | CPORFOBFIDPDLZ-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(C2=NC=CN2)C=C1NC(C3=CC=C(OCC4=CC=CC=N4)C=C3)=O.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AZ 12080282 dihydrochloride
参考文献 for AZ 12080282 dihydrochloride
参考文献是支持产品生物活性的出版物。
Yang et al (2012) Discovery of novel hedgehog antagonists from cell-based screening: isoteric modification of p38 bisamides as potent inhibitors of SMO. Bioorg.Med.Chem.Lett. 22 4907 PMID: 22704236
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关键词: AZ 12080282 dihydrochloride, AZ 12080282 dihydrochloride supplier, AZ12080282, dihydrochloride, hedgehog, signaling, signalling, inhibitors, inhibits, Hedgehog, Signaling, 4838, Tocris Bioscience
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