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Submit ReviewAZ 12216052
Discontinued Product
4832 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
说明： Positive allosteric modulator of mGlu8 receptors
化学名： 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide
纯度： ≥97% (HPLC)
生物活性 for AZ 12216052
AZ 12216052 is a positive allosteric modulator at mGlu8 receptors. Exhibits anxiolytic effects in mouse models of anxiety.
技术数据 for AZ 12216052
| 分子量 | 392.35 |
| 公式 | C19H22BrNOS |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 1290628-31-7 |
| PubChem ID | 73755190 |
| InChI Key | QKUYZJOTWYRWNF-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(CSCC(NC2=CC=C(C(C)CC)C=C2)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AZ 12216052
参考文献 for AZ 12216052
参考文献是支持产品生物活性的出版物。
Chruscicka et al (2013) Expression of metabotropic glutamate receptors in mammalian cells as a method for identification of new chemical compounds with drug-like activity. Pharmacol.Rep. 65 38
Duvoisin et al (2011) Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav.Brain Res. 221 50 PMID: 21382421
Duvoisin et al (2010) Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav.Brain Res. 212 168 PMID: 20385173
关键词: AZ 12216052, AZ 12216052 supplier, AZ12216052, anxiolytics, mGluR8, positive, allosteric, modulators, PAMs, Glutamate, (Metabotropic), Group, III, Receptors, 4832, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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