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说明： Potent and selective mGlu5 antagonist; brain penetrant
化学名： 3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
纯度： ≥98% (HPLC)
生物活性 for AZD 9272
AZD 9272 is a potent and selective mGlu5 antagonist (IC50 values are 2.6 and 7.6 nM for rat and human receptors, respectively). Exhibits >3900-fold selectivity for mGlu5 over other mGlu receptors. Also selective over a panel of other targets. Displays discriminative effects in rats. Orally bioavailable and brain penetrant.
技术数据 for AZD 9272
| 分子量 | 284.22 |
| 公式 | C14H6F2N4O |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 327056-26-8 |
| PubChem ID | 9838729 |
| InChI Key | RBSPCALDSNXWEP-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(C2=NOC(C3=CC(F)=CC(C#N)=C3)=N2)N=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AZD 9272
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 14.21 | 50 |
制备储备液 for AZD 9272
以下数据基于产品分子量 284.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.04 mL | 35.18 mL | 70.37 mL |
| 2.5 mM | 1.41 mL | 7.04 mL | 14.07 mL |
| 5 mM | 0.7 mL | 3.52 mL | 7.04 mL |
| 25 mM | 0.14 mL | 0.7 mL | 1.41 mL |
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产品说明书 for AZD 9272
参考文献 for AZD 9272
参考文献是支持产品生物活性的出版物。
Swedberg and Raboisson (2014) AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J.Pharmacol.Exp.Ther. 350 212 PMID: 24876235
Raboisson et al (2012) Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg.Med.Chem.Lett. 22 6974 PMID: 23046966
If you know of a relevant reference for AZD 9272, please let us know.
关键词: AZD 9272, AZD 9272 supplier, AZD9272, mGlu5, antagonists, metabotropic, glutamate, receptors, orally, bioavailable, brain, penetrant, potent, selective, Glutamate, (Metabotropic), Group, I, Receptors, 5613, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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