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β-Alanine

Cat. No. 0206 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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0206 has been discontinued.

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说明： Endogenous glycine agonist, more selective than taurine (Cat. No. 0209)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for β-Alanine

β-Alanine is a non-specific endogenous agonist at the inhibitory glycine receptor. More selective than taurine (Cat. No. 0209). Also distinguishes between GABA transporters (IC50 values are 19, 58, 110, 1320 and 5690 μM for rGAT-2, hGAT-3, rGAT-3, hBGT-3 and hGAT-1 respectively). Also MRGPRD agonist.

技术数据 for β-Alanine

分子量 89.09
公式 C3H7NO2
储存 Store at RT
CAS Number 107-95-9
PubChem ID 239
InChI Key UCMIRNVEIXFBKS-UHFFFAOYSA-N
Smiles NCCC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for β-Alanine

参考文献是支持产品生物活性的出版物。

Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219 PMID: 7851497

Saitoh et al (1994) A novel antagonist, phenylbenzene ω-phosphono-α-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br.J.Pharmacol. 113 165 PMID: 7812607

Schieden and Betz (1995) Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol.Pharmacol. 48 919 PMID: 7476923

Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890

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关键词: beta-Alanine, beta-Alanine supplier, Endogenous, glycine, agonists, selective, Taurine, GABA, uptake, inhibitors, inhibits, GAT-2, -3, receptor, GlyR, Glycine, Receptors, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, beta-alanine, β-alanine, MRGPRD, agonism, mas-related, g, protein-coupled, Mas-related, G, Protein-Coupled, 0206, Tocris Bioscience

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Beta-Alanine as a ligand of glycine receptors.
By Anonymous on 10/30/2019
分析类型： In Vitro
种属： Human
细胞系/组织： HEK-293

Glycine receptors of Alpha1+Beta subunit composition were expressed in HEK cells and then tested for functionality by beta-alanine application. As predicted, beta-alanine (1 mM) evoked a clear response, then fully blocked by strychnine (1 microM). Figure: response evoked by beta-alanine in a HEK-293 cell expressing glycine receptors.

Easily soluble compound, stable in water solution. Can be stored in fridge for months.

PMID: 19649170
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