β-Estradiol

Cat. No. 2824 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Endogenous ER agonist

别名： 17 β-Estradiol

化学名： (17β)-Estra-1,3,5(10)-triene-3,17-diol

纯度： ≥99% (HPLC)

引用文献 (5)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for β-Estradiol

β-Estradiol is an endogenous estrogen receptor (ER) agonist (K_i values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.

α-Estradiol also available.

技术数据 for β-Estradiol

分子量	272.38
公式	C₁₈H₂₄O₂
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	50-28-2
PubChem ID	5757
InChI Key	VOXZDWNPVJITMN-ZBRFXRBCSA-N
Smiles	[H][C@@]23CCC1=CC(O)=CC=C1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for β-Estradiol

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	27.24	100
	ethanol	20.43	75 温和加热

制备储备液 for β-Estradiol

以下数据基于产品分子量 272.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.67 mL	18.36 mL	36.71 mL
5 mM	0.73 mL	3.67 mL	7.34 mL
10 mM	0.37 mL	1.84 mL	3.67 mL
50 mM	0.07 mL	0.37 mL	0.73 mL

Molarity Calculator

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产品说明书 for β-Estradiol

分析证书/产品说明书

化学品安全技术说明书

参考文献 for β-Estradiol

参考文献是支持产品生物活性的出版物。

Kuiper et al (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138 863 PMID: 9048584

Thomas et al (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146 624 PMID: 15539556

If you know of a relevant reference for β-Estradiol, please let us know.

按标靶查看相关产品

关键词: beta-Estradiol, beta-Estradiol supplier, Endogenous, ER, agonists, Estrogen, Receptors, GPR30, beta-Estradiol, b-estradiol, β-estradiol, 17, β-Estradiol, beta-estradiol, GPER, 17b-Estradiol, and, Related, (GPER), 2824, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Estradiol 17B, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

5 篇 β-Estradiol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 β-Estradiol 的部分引用包括：

Seo et al (2019) A mechanical acupuncture instrument mitigates the endoplasmic reticulum stress and oxidative stress of ovariectomized rats. Integr Med Res 8 187 PMID: 31463191

Leal et al (2012) p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. PLoS One 7 e49817 PMID: 23239970

Al-Khyatt (2018) Selective oestrogen receptor antagonists inhibit oesophageal cancer cell proliferation in vitro. BMC Cancer 18 121 PMID: 29390981

Hood et al (2016) Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension. Hypertension 68 796 PMID: 27402919

Pastore et al (2016) Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells. Biol Reprod 94 139 PMID: 27170438

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Pathways for β-Estradiol

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.