Baicalein

Name: Baicalein
Brand: Tocris Bioscience
SKU: 1761

Cat. No. 1761 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1761 has been discontinued.

View all Lipoxygenases products.

说明： 5- and 12-Lipoxygenase inhibitor

化学名： 5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one

纯度： ≥98% (HPLC)

说明书

引用文献 (6)

生物活性技术数据说明书参考文献

生物活性 for Baicalein

Baicalein is an inhibitor of 5- and platelet 12-lipoxygenases (IC₅₀ values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G₁ and G₂ cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation. Also inhibits erastin-induced ferroptosis.

技术数据 for Baicalein

分子量	270.24
公式	C₁₅H₁₀O₅
储存	Desiccate at -20°C
纯度	≥98% (HPLC)
CAS Number	491-67-8
PubChem ID	5281605
InChI Key	FXNFHKRTJBSTCS-UHFFFAOYSA-N
Smiles	OC1=C(O)C(O)=C2C(=O)C=C(OC2=C1)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Baicalein

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Baicalein

参考文献是支持产品生物活性的出版物。

Hsu et al (2001) Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur.J.Pharmacol. 425 165 PMID: 11513834

Nakahata et al (2003) Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. Eur.J.Pharmacol. 461 1 PMID: 12568909

Sekiya and Okuda (1982) Selective inhibition of platelet lipoxygenase by baicalein. Biochem.Biophys.Res.Commun. 105 1090 PMID: 6807310

Hsieh et al (2007) Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway. Clin.Mol.Allergy 26 5 PMID: 18039391

Xie et al (2016) Identification of Baicalein as a ferroptosis inhibitor by natural product library screening. Biochem.Biophys.Res.Commun. 473 775 PMID: 27037021

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