BAN ORL 24

Name: BAN ORL 24
Brand: Tocris Bioscience
SKU: 3661

Cat. No. 3661 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3661 has been discontinued.

View all NOP Receptors products.

说明： Potent and selective NOP antagonist

化学名： (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide dihydrochloride

纯度： ≥97% (HPLC)

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for BAN ORL 24

Potent and selective NOP receptor antagonist (IC₅₀ values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). Inhibits nociceptin-induced stimulation of [³⁵S]-GTPγS binding and Ca²⁺ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo. Brain penetrant.

技术数据 for BAN ORL 24

分子量	506.51
公式	C₂₇H₃₅N₃O₂.2HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	1401463-54-4
PubChem ID	56840444
InChI Key	NEEVITHVDIQNJY-KHZPMNTOSA-N
Smiles	O=[C@@]([C@H]2CCCN2CC3=CC=CC=C3)NCCCN1CCC4(OCC5=C4C=CC=C5)CC1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BAN ORL 24

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BAN ORL 24

参考文献是支持产品生物活性的出版物。

Goto et al (2006) Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity. J.Med.Chem. 49 847 PMID: 16451050

Liao et al (2009) 1-Benzyl-N-[spiroisobenzofuran-1(³H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices. Eur.J.Pharmacol. 606 84 PMID: 19374842

Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50 PMID: 19445927

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关键词: BAN ORL 24, BAN ORL 24 supplier, BANORL24, potent, selective, NOP, ORL1, OP4, nociceptin, orphanin, FQ, opioids, receptor-like, 1, receptors, antagonists, Receptors, 3661, Tocris Bioscience

1 篇 BAN ORL 24 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BAN ORL 24 的部分引用包括：

Aatsinki et al (2014) MetF. induces PGC-1α expression and selectively affects hepatic PGC-1α functions. Am J Physiol Cell Physiol 171 2351 PMID: 24428821

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Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.