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Submit ReviewBanoxantrone dihydrochloride
说明： Prodrug topoisomerase II inhibitor
别名： AQ4N
化学名： 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for Banoxantrone dihydrochloride
Banoxantrone dihydrochloride is a bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.
技术数据 for Banoxantrone dihydrochloride
| 分子量 | 517.4 |
| 公式 | C22H28N4O6.2HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 252979-56-9 |
| PubChem ID | 72941779 |
| InChI Key | SBWCPHUXRZRTDP-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(O)C2=C1C(C(C(NCC[N+]([O-])(C)C)=CC=C3NCC[N+]([O-])(C)C)=C3C2=O)=O.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Banoxantrone dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 25.87 | 50 | |
| DMSO | 12.94 | 25 |
制备储备液 for Banoxantrone dihydrochloride
以下数据基于产品分子量 517.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.87 mL | 19.33 mL | 38.65 mL |
| 2.5 mM | 0.77 mL | 3.87 mL | 7.73 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.87 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.77 mL |
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产品说明书 for Banoxantrone dihydrochloride
参考文献 for Banoxantrone dihydrochloride
参考文献是支持产品生物活性的出版物。
Friery et al (2000) Enhancement of the anti-tumour effect of cyclophosph. by the bioreductive drugs AQ4N and tirapazamine. Br.J.Cancer 82 1469 PMID: 10780528
Patterson and McKeown (2000) AQ4N: a new approach to hypoxia-activated cancer chemotherapy. Br.J.Cancer 83 1589 PMID: 11104551
Mehibel et al (2009) Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N). Mol.Cancer Ther. 8 1261 PMID: 19435866
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关键词: Banoxantrone dihydrochloride, Banoxantrone dihydrochloride supplier, AQ4N, prodrug, hypoxia, hypoxic, cytotoxic, topoisomerase, II, inhibitors, inhibits, antitumor, antitumour, chemotherapeutics, DNA, Topoisomerase, 4219, Tocris Bioscience
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