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Submit ReviewBAY 1797
说明： Selective P2X4 antagonist
化学名： N-[3-(Aminosulfonyl)-4-(3-chlorophenoxy)phenyl]benzeneacetamide
纯度： ≥98% (HPLC)
生物活性 for BAY 1797
BAY 1797 is a selective purinergic P2X4 receptor antagonist (IC50 values are 108, 112 and 233 nM for the human, mouse and rat P2X4, respectively). It is selective for P2X4 over P2X3, P2X7, and P2X1 receptors (IC50 values are 8.3, 10.6 and >50 μM, respectively, for the human receptors). BAY 1797 dose-dependently reduces prostaglandin E2 levels and exhibits anti-inflammatory and analgesic effects in an in vivo model of inflammatory pain. Orally active.
许可信息
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 1797 probe summary on the SGC website.
技术数据 for BAY 1797
| 分子量 | 416.88 |
| 公式 | C20H17ClN2O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2055602-83-8 |
| PubChem ID | 124125214 |
| InChI Key | CSJYMAFXYMYNCK-UHFFFAOYSA-N |
| Smiles | NS(=O)(C1=C(C=CC(NC(CC2=CC=CC=C2)=O)=C1)OC3=CC(Cl)=CC=C3)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BAY 1797
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 41.69 | 100 | |
| ethanol | 41.69 | 100 |
制备储备液 for BAY 1797
以下数据基于产品分子量 416.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.4 mL | 11.99 mL | 23.99 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.8 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.4 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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产品说明书 for BAY 1797
参考文献 for BAY 1797
参考文献是支持产品生物活性的出版物。
Werner et al (2019) Discovery and characterization of the potent and selective P2X4 inhibitor N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and structure-guided amelioration of its CYP3A4 induction profile. J.Med.Chem. 62 11194 PMID: 31746599
If you know of a relevant reference for BAY 1797, please let us know.
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关键词: BAY 1797, BAY 1797 supplier, BAY1797, selective, antagonizes, antagonists, purinergic, P2X4, receptor, antinociceptive, anti-inflammatory, P2X, Receptors, 7573, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.