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Submit ReviewBay 36-7620
说明： mGlu1 inverse agonist
化学名： (3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one
纯度： ≥98% (HPLC)
生物活性 for Bay 36-7620
Bay 36-7620 is a selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.
许可信息
Sold for research purposes under agreement from Bayer
技术数据 for Bay 36-7620
| 分子量 | 278.35 |
| 公式 | C19H18O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 232605-26-4 |
| PubChem ID | 9903757 |
| InChI Key | CVIRWLJKDBYYOG-MJGOQNOKSA-N |
| Smiles | C=C1C[C@@]2([H])[C@@](C(OC2)=O)(CC3=CC(C=CC=C4)=C4C=C3)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Bay 36-7620
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 27.84 | 100 | |
| ethanol | 27.84 | 100 |
制备储备液 for Bay 36-7620
以下数据基于产品分子量 278.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.59 mL | 17.96 mL | 35.93 mL |
| 5 mM | 0.72 mL | 3.59 mL | 7.19 mL |
| 10 mM | 0.36 mL | 1.8 mL | 3.59 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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产品说明书 for Bay 36-7620
参考文献 for Bay 36-7620
参考文献是支持产品生物活性的出版物。
Carroll et al (2001) BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol.Pharmacol. 59 965 PMID: 11306677
De Vry et al (2001) Neuroprotective and behavioural effects of the selective metabotropic glutamate mGlu1 receptor antagonist BAY 36-7620. Eur.J.Pharmacol. 428 203 PMID: 11675037
Gil-Sanz et al (2007) Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice. Cereb.Cortex 18 1653 PMID: 18024992
If you know of a relevant reference for Bay 36-7620, please let us know.
关键词: Bay 36-7620, Bay 36-7620 supplier, Bay367620, selective, non-competitive, mGlu1, mGluR1, antagonists, receptors, inverse, agonists, metabotropic, glutamate, Glutamate, (Metabotropic), Group, I, Receptors, 2501, Tocris Bioscience
9 篇 Bay 36-7620 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Bay 36-7620 的部分引用包括：
Sexton et al (2018) Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer. Sci Rep 8 16008 PMID: 30375476
Dolfi et al (2017) R.zole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. Oncotarget 8 44639 PMID: 28591718
Speyer et al (2012) Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer. Breast Cancer Res Treat 132 565 PMID: 21681448
Foong (2009) mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum. Front Neurosci 3 46 PMID: 20582273
Le et al (2010) The glutamate release inhibitor R.zole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol 130 2240 PMID: 20505744
Tronson et al (2010) Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear. Autophagy 68 1007 PMID: 21075228
Pallo et al (2016) Mechanisms of tau and Aβ-induced excitotoxicity. Brain Res 1634 119 PMID: 26731336
Veettil et al (2014) Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. PLoS Pathog 10 e1004389 PMID: 25299066
Wall et al (2014) Disruption of GRM1-mediated signalling using R.zole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res 27 263 PMID: 24330389
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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