主页 / 药理学 / Ion Channels / Transient Receptor Potential Channels / TRPA1 / TRPA1 Blockers / BAY 390

BAY 390

Cat. No. 7978 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective TRPA1 antagonist. Brain penetrant and orally bioavailable
化学名： (1R,2R)-2-[(4-Fluorophenyl)amino]-1-(trifluoromethyl)cyclohexanol
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAY 390

BAY 390 is a potent and selective transient receptor potential ankyrin 1 (TRPA1) antagonist (IC50 values are 16, 63 and 82 nM for hTRPA1 FLIPR, rTRPA1 FLIPR and hTRPA1 Ephys, respectively). In vivo, BAY 390 exhibits efficacy in rat models of inflammatory and neuropathic pain. BAY 390 is orally bioavailable and brain penetrant. Suitable to use as an in vitro or in vivo probe to investigate the roles of TRPA1 in models of acute, inflammatory, and neuropathic pain.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 390 probe summary on the SGC website.

技术数据 for BAY 390

分子量 277.26
公式 C13H15F4NO
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2741956-55-6
PubChem ID 155539293
InChI Key IESAJAZKMLPVIB-VXGBXAGGSA-N
Smiles FC(F)([C@]1(CCCC[C@H]1NC2=CC=C(F)C=C2)O)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 390

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.73 100
ethanol 27.73 100

制备储备液 for BAY 390

以下数据基于产品分子量 277.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.61 mL 18.03 mL 36.07 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
10 mM 0.36 mL 1.8 mL 3.61 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for BAY 390

参考文献是支持产品生物活性的出版物。

Mesch et al (2023) Discovery of BAY-390, a selective CNS penetrant chemical probe as transient receptor potential ankyrin 1 (TRPA1) antagonist. J.Med.Chem. 66 1583 PMID: 36622903

If you know of a relevant reference for BAY 390, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 TRPA1 Blockers

关键词: BAY 390, BAY 390 supplier, BAY390, potent, selective, transient, receptor, potential, A1, TRPA1, antagonists, antagonism, orally, bioavailable, in, vivo, brain, penetrant, blockers, inflammatory, neuropathic, pain, probe, 7978, Tocris Bioscience

篇 BAY 390 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 BAY 390 的引用文献。 您是否知道使用了 Tocris BAY 390 的优秀论文？ 请告知我们.

BAY 390 的评论

目前没有该产品的评论。 Be the first to review BAY 390 and earn rewards!

Have you used BAY 390?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review