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BAY 593

Cat. No. 8113 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Geranylgeranyltransferase-I (GGTase-I) inhibitor
化学名： (2R)-3,3,3-Trifluoro-2-methoxy-1-[(7R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-1-propanone hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAY 593

BAY 593 is a geranylgeranyltransferase-I (GGTase-I) inhibitor. Blocks activation of Rho-GTPases to inactivate YAP1/TAZ signaling. Dose-dependently inhibits growth of tumors in xenograft mouse models (IC50 values are 38.4 nM and 564 nM in MT-1080 and MDA-MB-231 cells respectively) and PXF 541 xenografts. Orally bioavailable and suitable for use in vivo.

技术数据 for BAY 593

分子量 513
公式 C26H31F3N2O3.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2413020-57-0
InChI Key OCVVGTVEVMMMCR-XSHMPXIGSA-N
Smiles COC1=C(C=CC=C1)[C@H]2C3(CCNC2)CCN(CC3)C([C@](OC)(C4=CC=CC=C4)C(F)(F)F)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 593

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 51.3 100

制备储备液 for BAY 593

以下数据基于产品分子量 513。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.75 mL 19.49 mL
5 mM 0.39 mL 1.95 mL 3.9 mL
10 mM 0.19 mL 0.97 mL 1.95 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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参考文献 for BAY 593

参考文献是支持产品生物活性的出版物。

Graham et al (2024) Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. Cell.Chem.Biol. 31 1247 PMID: 38537632

If you know of a relevant reference for BAY 593, please let us know.

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关键词: BAY 593, BAY 593 supplier, BAY593, GGTase, inhibitor, inhibitors, inhibits, Rho-GTPase, GTPase, YAP1, TAZ, Other, Transferases, 8113, Tocris Bioscience

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